ISSN 1662-4009 (online)

ey0016.2-15 | Impact of Maternal Diet on Hypothalamic-Pituitary-Adrenal Function | ESPEYB16

2.15. Maternal high fat diet programs hypothalamic-pituitary-adrenal function in adult rat offspring

X Niu , X Wu , A Ying , B Shao , X Li , W Zhang , C Lin , Y Lin

To read the full abstract: Psychoneuroendocrinology. 2018 Dec 6;102:128–138.This study investigated whether maternal high fat diet (HFD) exposure during rat pregnancy and lactation can alter the hypothalamic-pituitary-adrenal (HPA) in adult male offspring.Maternal diet and metabolic status are important factors which influence the intrauterine and early postna...

ey0015.11-14 | Adipose tissue – a main source of miRNAs | ESPEYB15

11.14 Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity

W Ying , M Riopel , G Bandyopadhyay , Y Dong , A Birmingham , J Bae Seo , J Ofrecio , J Wollam , A Hernandez-Carretero , W Fu , P Li , J Olefsky

To read the full abstract: Cell 2017, Volume 171, Issue 2Here, the group of Jerrold Olefsky identified adipose tissue macrophages as important sources of microRNAs regulating metabolic processes not only within the adipose tissue depot, but also in an endocrine way in other distant tissues. The application of exosomes derived from ATMs isolated from obese mice caused insulin resistance both ...

ey0018.5-7 | Advances in clinical practice | ESPEYB18

5.7. Effect of vitamin D3 supplementation on severe asthma exacerbations in children with asthma and low vitamin D levels: the VDKA randomized clinical trial

Forno Erick , Bacharier Leonard B , Phipatanakul Wanda , Guilbert Theresa W , Cabana Michael D , Ross Kristie , Covar Ronina , Gern James E , Rosser Franziska J , Blatter Joshua , Durrani Sandy , Han Yueh-Ying , Wisniewski Stephen R , Celedon Juan C

JAMA. 2020 Aug 25;324(8):752–760. doi: 10.1001/jama.2020.12384. Abstract: https://pubmed.ncbi.nlm.nih.gov/32840597/In brief: Several observational studies have linked low serum 25(OH)D levels to severe asthma exacerbations, lower lung function, and reduced response to corticosteroids. In this randomized controlled trial...

ey0018.5-12 | Advances in skeletal biology | ESPEYB18

5.12. Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

McDonald Michelle M , Khoo Weng Hua , Ng Pei Ying , Xiao Ya , Zamerli Jad , Thatcher Peter , Kyaw Wunna , Pathmanandavel Karrnan , Grootveld Abigail K , Moran Imogen , Butt Danyal , Nguyen Akira , Corr Alexander , Warren Sean , Biro Mate , Butterfield Natalie C , Guilfoyle Siobhan E , Komla-Ebri Davide , Dack Michael R G , Dewhurst Hannah F , Logan John G , Li Yongxiao , Mohanty Sindhu T , Byrne Niall , Terry Rachael L , Simic Marija K , Chai Ryan , Quinn Julian M W , Youlten Scott E , Pettitt Jessica A , Abi-Hanna David , Jain Rohit , Weninger Wolfgang , Lundberg Mischa , Sun Shuting , Ebetino Frank H , Timpson Paul , Lee Woei Ming , Baldock Paul A , Rogers Michael J , Brink Robert , Williams Graham R , Bassett J H Duncan , Kemp John P , Pavlos Nathan J , Croucher Peter I , Phan Tri Giang

Cell. 2021 Mar 4;184(5):1330–1347.e13 Abstract: https://pubmed.ncbi.nlm.nih.gov/33636130/In brief: This paper reports an alternative cell fate for multinucleated, bone-resorbing osteoclasts and shows that they may undergo fission into smaller osteomorphs. The findings challenge the current dogma that osteoclasts primarily differentiate from hematopoietic progenitor cells and a...